About Signal transducing adapter molecule 1
Signal transducing adapter molecule 1 (STAM) is a protein
from Homo sapiens identified by UniProt accession
Q92783, 540 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Signal transducing adapter molecule 1 |
|---|
| UniProt accession | Q92783 |
|---|
| Gene | STAM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 540 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- listeriosis · score 0.37
- aspartate aminotransferase measurement · score 0.34
- lung adenocarcinoma · score 0.26
- breast adenocarcinoma · score 0.25
- ovarian cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.19
- endometrial cancer · score 0.18
- clear cell renal carcinoma · score 0.17
- nonpapillary renal cell carcinoma · score 0.08
- hemoglobin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92783-F1 | alphafold | PREDICTED | 67.78 | — |
Amino-acid sequence (540 residues)
MPLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK NDPQLSLISA MIKNLKEQGV TFPAIGSQAA EQAKASPALV AKDPGTVANK KEEEDLAKAI ELSLKEQRQQ STTLSTLYPS TSSLLTNHQH EGRKVRAIYD FEAAEDNELT FKAGEIITVL DDSDPNWWKG ETHQGIGLFP SNFVTADLTA EPEMIKTEKK TVQFSDDVQV ETIEPEPEPA FIDEDKMDQL LQMLQSTDPS DDQPDLPELL HLEAMCHQMG PLIDEKLEDI DRKHSELSEL NVKVMEALSL YTKLMNEDPM YSMYAKLQNQ PYYMQSSGVS GSQVYAGPPP SGAYLVAGNA QMSHLQSYSL PPEQLSSLSQ AVVPPSANPA LPSQQTQAAY PNTMVSSVQG NTYPSQAPVY SPPPAATAAA ATADVTLYQN AGPNMPQVPN YNLTSSTLPQ PGGSQQPPQP QQPYSQKALL
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