About Prospero homeobox protein 1
Prospero homeobox protein 1 (PROX1) is a protein
from Homo sapiens identified by UniProt accession
Q92786, 737 residues long.
MolForge cross-references it against 0 known binders and
297 disease associations.
Target properties
| Protein name | Prospero homeobox protein 1 |
|---|
| UniProt accession | Q92786 |
|---|
| Gene | PROX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 737 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (297)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.50
- type 2 diabetes mellitus · score 0.50
- hematocrit · score 0.49
- erythrocyte count · score 0.49
- sex hormone-binding globulin measurement · score 0.48
- diabetes mellitus · score 0.46
- glucose measurement · score 0.45
- red blood cell density measurement · score 0.45
- HbA1c measurement · score 0.44
- fasting blood glucose measurement · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92786-F1 | alphafold | PREDICTED | 60.45 | — |
Amino-acid sequence (737 residues)
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDMDRLCDE HLRAKRARVE NIIRGMSHSP SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK QQLEDMQKQL RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE TLKQELNTAM SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ SASGPAAGGH HQPLHQSPLS ATTGFTTSTF RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP AHPPSTAEGL SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST EELSITRDCE LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK DVDPSWKKAI YKVICKLDSE VPEIFKSPNC LQELLHE
Explore Prospero homeobox protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets