About Histone-lysine N-methyltransferase EZH1
Histone-lysine N-methyltransferase EZH1 (EZH1) is a protein
from Homo sapiens identified by UniProt accession
Q92800, 747 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Histone-lysine N-methyltransferase EZH1 |
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| UniProt accession | Q92800 |
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| Gene | EZH1 |
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| Organism | Homo sapiens |
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| Length | 747 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (50)
Diseases linked to this target (Open Targets).
- body height · score 0.27
- Neurodevelopmental disorder · score 0.23
- BMI-adjusted waist circumference · score 0.17
- waist-hip ratio · score 0.16
- type 2 diabetes mellitus · score 0.09
- BMI-adjusted waist-hip ratio · score 0.08
- triple-negative breast cancer · score 0.07
- breast cancer · score 0.07
- triglyceride measurement · score 0.07
- bronchopulmonary dysplasia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92800-F1 | alphafold | PREDICTED | 74.59 | — |
Amino-acid sequence (747 residues)
MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN FMVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG EELFFDYRYS QADALKYVGI ERETDVL
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