About G protein-activated inward rectifier potassium channel 3
G protein-activated inward rectifier potassium channel 3 (KCNJ9) is a protein
from Homo sapiens identified by UniProt accession
Q92806, 393 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | G protein-activated inward rectifier potassium channel 3 |
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| UniProt accession | Q92806 |
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| Gene | KCNJ9 |
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| Organism | Homo sapiens |
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| Length | 393 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.22
- granulocyte count · score 0.20
- esophageal cancer · score 0.10
- red blood cell density measurement · score 0.07
- myeloperoxidase deficiency · score 0.05
- X-linked severe congenital neutropenia · score 0.05
- Blackfan-Diamond anemia · score 0.05
- nonimmune chronic idiopathic neutropenia of adults · score 0.05
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
- atypical teratoid rhabdoid tumor · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92806-F1 | alphafold | PREDICTED | 85.23 | — |
Amino-acid sequence (393 residues)
MAQENAAFSP GQEEPPRRRG RQRYVEKDGR CNVQQGNVRE TYRYLTDLFT TLVDLQWRLS LLFFVLAYAL TWLFFGAIWW LIAYGRGDLE HLEDTAWTPC VNNLNGFVAA FLFSIETETT IGYGHRVITD QCPEGIVLLL LQAILGSMVN AFMVGCMFVK ISQPNKRAAT LVFSSHAVVS LRDGRLCLMF RVGDLRSSHI VEASIRAKLI RSRQTLEGEF IPLHQTDLSV GFDTGDDRLF LVSPLVISHE IDAASPFWEA SRRALERDDF EIVVILEGMV EATGMTCQAR SSYLVDEVLW GHRFTSVLTL EDGFYEVDYA SFHETFEVPT PSCSARELAE AAARLDAHLY WSIPSRLDEK VEEEGAGEGA GGEAGADKEQ NGCLPPPESE SKV
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