About Type II iodothyronine deiodinase
Type II iodothyronine deiodinase (DIO2) is a protein
from Homo sapiens identified by UniProt accession
Q92813, 273 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Type II iodothyronine deiodinase |
|---|
| UniProt accession | Q92813 |
|---|
| Gene | DIO2 |
|---|
| Organism | Homo sapiens |
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| Length | 273 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (154)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.40
- grip strength measurement · score 0.33
- monocyte count · score 0.33
- PHF-tau measurement · score 0.32
- thyroxine measurement · score 0.32
- sitting height measurement · score 0.28
- lung adenocarcinoma · score 0.19
- rosacea severity measurement · score 0.18
- cutaneous melanoma · score 0.16
- body height · score 0.11
Amino-acid sequence (273 residues)
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGL RCVWKSFLLD AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP ERPLVVNFGS ATUPPFTSQL PAFRKLVEEF SSVADFLLVY IDEAHPSDGW AIPGDSSLSF EVKKHQNQED RCAAAQQLLE RFSLPPQCRV VADRMDNNAN IAYGVAFERV CIVQRQKIAY LGGKGPFSYN LQEVRHWLEK NFSKRUKKTR LAG
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