Hyaluronan synthase 2 (HAS2)

About Hyaluronan synthase 2

Hyaluronan synthase 2 (HAS2) is a protein from Homo sapiens identified by UniProt accession Q92819, 552 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.

Target properties

Protein name	Hyaluronan synthase 2
UniProt accession	Q92819
Gene	HAS2
Organism	Homo sapiens
Length	552 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (223)

Diseases linked to this target (Open Targets).

balding measurement · score 0.39
aortic measurement · score 0.39
hemoglobin measurement · score 0.36
hematocrit · score 0.33
erythrocyte count · score 0.30
red blood cell density measurement · score 0.28
body height · score 0.28
mean corpuscular hemoglobin concentration · score 0.27
chin morphology measurement · score 0.20
diverticulitis · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92819-F1	alphafold	PREDICTED	90.61	—

Amino-acid sequence (552 residues)

MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG AFLASHLIIQ SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR KCLQSVKRLT YPGIKVVMVI DGNSEDDLYM MDIFSEVMGR DKSATYIWKN NFHEKGPGET DESHKESSQH VTQLVLSNKS ICIMQKWGGK REVMYTAFRA LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ QTRWSKSYFR EWLYNAMWFH KHHLWMTYEA IITGFFPFFL IATVIQLFYR GKIWNILLFL LTVQLVGLIK SSFASCLRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP VSVWFTILLG GVIFTIYKES KRPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR KKGQQYDMVL DV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards