About Gamma-glutamyl hydrolase
Gamma-glutamyl hydrolase (GGH) is a protein
from Homo sapiens identified by UniProt accession
Q92820, 318 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Gamma-glutamyl hydrolase |
|---|
| UniProt accession | Q92820 |
|---|
| Gene | GGH |
|---|
| Organism | Homo sapiens |
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| Length | 318 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.43
- calcium measurement · score 0.37
- hemoglobin measurement · score 0.29
- monocyte percentage of leukocytes · score 0.21
- neoplasm · score 0.09
- cancer · score 0.08
- systolic blood pressure · score 0.06
- C-reactive protein measurement · score 0.05
- lung carcinoma · score 0.05
- triple-negative breast cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92820-F1 | alphafold | PREDICTED | 93.26 | — |
Amino-acid sequence (318 residues)
MASPGCLLCV LGLLLCGAAS LELSRPHGDT AKKPIIGILM QKCRNKVMKN YGRYYIAASY VKYLESAGAR VVPVRLDLTE KDYEILFKSI NGILFPGGSV DLRRSDYAKV AKIFYNLSIQ SFDDGDYFPV WGTCLGFEEL SLLISGECLL TATDTVDVAM PLNFTGGQLH SRMFQNFPTE LLLSLAVEPL TANFHKWSLS VKNFTMNEKL KKFFNVLTTN TDGKIEFIST MEGYKYPVYG VQWHPEKAPY EWKNLDGISH APNAVKTAFY LAEFFVNEAR KNNHHFKSES EEEKALIYQF SPIYTGNISS FQQCYIFD
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