About Proto-oncogene FRAT1
Proto-oncogene FRAT1 (FRAT1) is a protein
from Homo sapiens identified by UniProt accession
Q92837, 279 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Proto-oncogene FRAT1 |
|---|
| UniProt accession | Q92837 |
|---|
| Gene | FRAT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 279 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (72)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.34
- leukocyte count · score 0.32
- myeloid white cell count · score 0.29
- eosinophil count · score 0.21
- lymphocyte count · score 0.20
- refractive error measurement · score 0.16
- type 2 diabetes mellitus · score 0.15
- monocyte count · score 0.13
- sum of basophil and neutrophil counts · score 0.12
- electrocardiography · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92837-F1 | alphafold | PREDICTED | 59.82 | — |
Amino-acid sequence (279 residues)
MPCRREEEEE AGEEAEGEEE EEDSFLLLQQ SVALGSSGEV DRLVAQIGET LQLDAAQHSP ASPCGPPGAP LRAPGPLAAA VPADKARSPA VPLLLPPALA ETVGPAPPGV LRCALGDRGR VRGRAAPYCV AELATGPSAL SPLPPQADLD GPPGAGKQGI PQPLSGPCRR GWLRGAAASR RLQQRRGSQP ETRTGDDDPH RLLQQLVLSG NLIKEAVRRL HSRRLQLRAK LPQRPLLGPL SAPVHEPPSP RSPRAACSDP GASGRAQLRT GDGVLVPGS
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