Ectodysplasin-A (EDA)

About Ectodysplasin-A

Ectodysplasin-A (EDA) is a protein from Homo sapiens identified by UniProt accession Q92838, 391 residues long. MolForge cross-references it against 0 known binders and 589 disease associations.

Target properties

Protein name	Ectodysplasin-A
UniProt accession	Q92838
Gene	EDA
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (589)

Diseases linked to this target (Open Targets).

X-linked hypohidrotic ectodermal dysplasia · score 0.85
tooth agenesis, selective, X-linked, 1 · score 0.78
neurodegenerative disease · score 0.50
hypohidrotic ectodermal dysplasia · score 0.48
tooth agenesis · score 0.46
genetic disorder · score 0.36
ectodermal dysplasia syndrome · score 0.34
tooth agenesis, selective, 2 · score 0.34
Abnormality of the dentition · score 0.27
ringed hair disease · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92838-F1	alphafold	PREDICTED	69.63	—

Amino-acid sequence (391 residues)

MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI AVKMVHADIS INMSKHTTFF GAIRLGEAPA S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards