About Hyaluronan synthase 1
Hyaluronan synthase 1 (HAS1) is a protein
from Homo sapiens identified by UniProt accession
Q92839, 577 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Hyaluronan synthase 1 |
|---|
| UniProt accession | Q92839 |
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| Gene | HAS1 |
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| Organism | Homo sapiens |
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| Length | 577 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (77)
Diseases linked to this target (Open Targets).
- grip strength measurement · score 0.33
- myoepithelial tumor · score 0.11
- cutaneous melanoma · score 0.11
- Miyoshi myopathy · score 0.09
- melanoma · score 0.08
- eosinophil peroxidase deficiency · score 0.05
- X-linked severe congenital neutropenia · score 0.05
- Blackfan-Diamond anemia · score 0.05
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
- nonimmune chronic idiopathic neutropenia of adults · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92839-F1 | alphafold | PREDICTED | 88.39 | — |
Amino-acid sequence (577 residues)
MRQDAPKPTP AACRCSGLAR RVLTIAFALL ILGLMTWAYA AGVPLASDRY GLLAFGLYGA FLSAHLVAQS LFAYLEHRRV AAAARGPLDA ATARSVALTI SAYQEDPAYL RQCLASARAL LYPRARLRVL MVVDGNRAED LYMVDMFREV FADEDPATYV WDGNYHQPWE PAAAGAVGAG AYREVEAEDP GRLAVEALVR TRRCVCVAQR WGGKREVMYT AFKALGDSVD YVQVCDSDTR LDPMALLELV RVLDEDPRVG AVGGDVRILN PLDSWVSFLS SLRYWVAFNV ERACQSYFHC VSCISGPLGL YRNNLLQQFL EAWYNQKFLG THCTFGDDRH LTNRMLSMGY ATKYTSRSRC YSETPSSFLR WLSQQTRWSK SYFREWLYNA LWWHRHHAWM TYEAVVSGLF PFFVAATVLR LFYAGRPWAL LWVLLCVQGV ALAKAAFAAW LRGCLRMVLL SLYAPLYMCG LLPAKFLALV TMNQSGWGTS GRRKLAANYV PLLPLALWAL LLLGGLVRSV AHEARADWSG PSRAAEAYHL AAGAGAYVGY WVAMLTLYWV GVRRLCRRRT GGYRVQV
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