About TRAF family member-associated NF-kappa-B activator
TRAF family member-associated NF-kappa-B activator (TANK) is a protein
from Homo sapiens identified by UniProt accession
Q92844, 425 residues long.
MolForge cross-references it against 0 known binders and
262 disease associations.
Target properties
| Protein name | TRAF family member-associated NF-kappa-B activator |
|---|
| UniProt accession | Q92844 |
|---|
| Gene | TANK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 425 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (262)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.48
- intelligence · score 0.46
- mathematical ability · score 0.41
- cognitive function measurement · score 0.39
- hypothyroidism · score 0.38
- smoking status measurement · score 0.37
- chronotype measurement · score 0.32
- peripheral neuropathy · score 0.31
- HIV-1 infection · score 0.31
- response to reverse transcriptase inhibitor · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92844-F1 | alphafold | PREDICTED | 59.50 | — |
Amino-acid sequence (425 residues)
MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV RRQEVSSPRK ETSARSLGSP LLHERGNIEK TFWDLKEEFH KICMLAKAQK DHLSKLNIPD TATETQCSVP IQCTDKTDKQ EALFKPQAKD DINRGAPSIT SVTPRGLCRD EEDTSFESLS KFNVKFPPMD NDSTFLHSTP ERPGILSPAT SEAVCQEKFN MEFRDNPGNF VKTEETLFEI QGIDPIASAI QNLKTTDKTK PSNLVNTCIR TTLDRAACLP PGDHNALYVN SFPLLDPSDA PFPSLDSPGK AIRGPQQPIW KPFPNQDSDS VVLSGTDSEL HIPRVCEFCQ AVFPPSITSR GDFLRHLNSH FNGET
Explore TRAF family member-associated NF-kappa-B activator with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets