About Caspase-10
Caspase-10 (CASP10) is a protein
from Homo sapiens identified by UniProt accession
Q92851, 521 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Caspase-10 |
|---|
| UniProt accession | Q92851 |
|---|
| Gene | CASP10 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 521 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- autoimmune lymphoproliferative syndrome type 2A · score 0.67
- gastric cancer · score 0.53
- non-Hodgkins lymphoma · score 0.46
- autoimmune lymphoproliferative syndrome · score 0.42
- lymphoma · score 0.41
- mean corpuscular hemoglobin concentration · score 0.40
- gastric carcinoma · score 0.37
- mean corpuscular hemoglobin · score 0.35
- mean platelet volume · score 0.29
- chronic lymphocytic leukemia · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92851-F1 | alphafold | PREDICTED | 68.81 | — |
Amino-acid sequence (521 residues)
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
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