About Transcription factor ATOH1
Transcription factor ATOH1 (ATOH1) is a protein
from Homo sapiens identified by UniProt accession
Q92858, 354 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Transcription factor ATOH1 |
|---|
| UniProt accession | Q92858 |
|---|
| Gene | ATOH1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 354 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (185)
Diseases linked to this target (Open Targets).
- facial morphology measurement · score 0.25
- colorectal adenoma · score 0.24
- colorectal cancer · score 0.24
- body mass index · score 0.16
- intelligence · score 0.14
- self reported educational attainment · score 0.14
- hypertension · score 0.14
- smoking status measurement · score 0.12
- pontocerebellar hypoplasia · score 0.12
- Global developmental delay · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92858-F1 | alphafold | PREDICTED | 59.23 | — |
Amino-acid sequence (354 residues)
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS
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