Deoxyribonuclease-1-like 2 (DNASE1L2)

About Deoxyribonuclease-1-like 2

Deoxyribonuclease-1-like 2 (DNASE1L2) is a protein from Homo sapiens identified by UniProt accession Q92874, 299 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.

Target properties

Protein name	Deoxyribonuclease-1-like 2
UniProt accession	Q92874
Gene	DNASE1L2
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (141)

Diseases linked to this target (Open Targets).

bipolar disorder · score 0.09
MALT lymphoma · score 0.07
brachydactyly type C · score 0.06
uncombable hair syndrome · score 0.06
alkaline phosphatase measurement · score 0.06
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
Meckel's diverticulum · score 0.05
hemoglobin D disease · score 0.05
Griscelli syndrome type 3 · score 0.05
delta-beta-thalassemia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92874-F1	alphafold	PREDICTED	89.67	—

Amino-acid sequence (299 residues)

MGGPRALLAA LWALEAAGTA ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL AGYDLALVQE VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM YLFVYRKDAV SVVDTYLYPD PEDVFSREPF VVKFSAPGTG ERAPPLPSRR ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI DALYDVYLDV IDKWGTDDML FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV GNSDCAYDRI VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards