CUGBP Elav-like family member 1 (CELF1)

About CUGBP Elav-like family member 1

CUGBP Elav-like family member 1 (CELF1) is a protein from Homo sapiens identified by UniProt accession Q92879, 486 residues long. MolForge cross-references it against 0 known binders and 258 disease associations.

Target properties

Protein name	CUGBP Elav-like family member 1
UniProt accession	Q92879
Gene	CELF1
Organism	Homo sapiens
Length	486 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (258)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
body mass index · score 0.21
age at menarche · score 0.18
platelet count · score 0.18
Antiglaucoma preparations and miotics use measurement · score 0.18
high density lipoprotein cholesterol measurement · score 0.16
body fat percentage · score 0.16
open-angle glaucoma · score 0.14
reticulocyte measurement · score 0.14
aspartate aminotransferase measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92879-F1	alphafold	PREDICTED	66.48	—

Amino-acid sequence (486 residues)

MNGTLDHPDQ PDLDAIKMFV GQVPRTWSEK DLRELFEQYG AVYEINVLRD RSQNPPQSKG CCFVTFYTRK AALEAQNALH NMKVLPGMHH PIQMKPADSE KNNAVEDRKL FIGMISKKCT ENDIRVMFSS FGQIEECRIL RGPDGLSRGC AFVTFTTRAM AQTAIKAMHQ AQTMEGCSSP MVVKFADTQK DKEQKRMAQQ LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAS SGNLNTLSSL HPMGGLNAMQ LQNLAALAAA ASAAQNTPSG TNALTTSSSP LSVLTSSGSS PSSSSSNSVN PIASLGALQT LAGATAGLNV GSLAGMAALN GGLGSSGLSN GTGSTMEALT QAYSGIQQYA AAALPTLYNQ NLLTQQSIGA AGSQKEGPEG ANLFIYHLPQ EFGDQDLLQM FMPFGNVVSA KVFIDKQTNL SKCFGFVSYD NPVSAQAAIQ SMNGFQIGMK RLKVQLKRSK NDSKPY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards