About BLOC-3 complex member HPS1
BLOC-3 complex member HPS1 (HPS1) is a protein
from Homo sapiens identified by UniProt accession
Q92902, 700 residues long.
MolForge cross-references it against 0 known binders and
167 disease associations.
Target properties
| Protein name | BLOC-3 complex member HPS1 |
|---|
| UniProt accession | Q92902 |
|---|
| Gene | HPS1 |
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| Organism | Homo sapiens |
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| Length | 700 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (167)
Diseases linked to this target (Open Targets).
- Hermansky-Pudlak syndrome · score 0.81
- oculocutaneous albinism · score 0.47
- pulmonary fibrosis · score 0.47
- inflammatory bowel disease · score 0.47
- hemorrhage · score 0.46
- Hermansky-Pudlak syndrome with pulmonary fibrosis · score 0.46
- genetic disorder · score 0.41
- lung disease · score 0.37
- calcium measurement · score 0.25
- blood phosphate measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92902-F1 | alphafold | PREDICTED | 80.54 | — |
Amino-acid sequence (700 residues)
MKCVLVATEG AEVLFYWTDQ EFEESLRLKF GQSENEEEEL PALEDQLSTL LAPVIISSMT MLEKLSDTYT CFSTENGNFL YVLHLFGECL FIAINGDHTE SEGDLRRKLY VLKYLFEVHF GLVTVDGHLI RKELRPPDLA QRVQLWEHFQ SLLWTYSRLR EQEQCFAVEA LERLIHPQLC ELCIEALERH VIQAVNTSPE RGGEEALHAF LLVHSKLLAF YSSHSASSLR PADLLALILL VQDLYPSEST AEDDIQPSPR RARSSQNIPV QQAWSPHSTG PTGGSSAETE TDSFSLPEEY FTPAPSPGDQ SSGSTIWLEG GTPPMDALQI AEDTLQTLVP HCPVPSGPRR IFLDANVKES YCPLVPHTMY CLPLWQGINL VLLTRSPSAP LALVLSQLMD GFSMLEKKLK EGPEPGASLR SQPLVGDLRQ RMDKFVKNRG AQEIQSTWLE FKAKAFSKSE PGSSWELLQA CGKLKRQLCA IYRLNFLTTA PSRGGPHLPQ HLQDQVQRLM REKLTDWKDF LLVKSRRNIT MVSYLEDFPG LVHFIYVDRT TGQMVAPSLN CSQKTSSELG KGPLAAFVKT KVWSLIQLAR RYLQKGYTTL LFQEGDFYCS YFLWFENDMG YKLQMIEVPV LSDDSVPIGM LGGDYYRKLL RYYSKNRPTE AVRCYELLAL HLSVIPTDLL VQQAGQLARR LWEASRIPLL
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