About Phosphatidate cytidylyltransferase 1
Phosphatidate cytidylyltransferase 1 (CDS1) is a protein
from Homo sapiens identified by UniProt accession
Q92903, 461 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Phosphatidate cytidylyltransferase 1 |
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| UniProt accession | Q92903 |
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| Gene | CDS1 |
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| Organism | Homo sapiens |
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| Length | 461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- white matter microstructure measurement · score 0.08
- peak expiratory flow · score 0.06
- interstitial lung disease · score 0.06
- type 2 diabetes mellitus · score 0.06
- adolescent idiopathic scoliosis · score 0.06
- azoospermia · score 0.05
- Drugs used in diabetes use measurement · score 0.04
- pancreatic adenocarcinoma · score 0.04
- male infertility with teratozoospermia due to single gene mutation · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92903-F1 | alphafold | PREDICTED | 80.76 | — |
Amino-acid sequence (461 residues)
MLELRHRGSC PGPREAVSPP HREGEAAGGD HETESTSDKE TDIDDRYGDL DSRTDSDIPE IPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF FLIIYMGSFM LMLLVLGIQV KCFHEIITIG YRVYHSYDLP WFRTLSWYFL LCVNYFFYGE TVADYFATFV QREEQLQFLI RYHRFISFAL YLAGFCMFVL SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI WFLVPISSVI CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVVF GFIAAYVLSK YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ TYSLPPFLKA VLRQERVSLY PFQIHSIALS TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF DCQYLMATFV HVYITSFIRG PNPSKVLQQL LVLQPEQQLN IYKTLKTHLI EKGILQPTLK V
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