Deleted in azoospermia-like (DAZL)

About Deleted in azoospermia-like

Deleted in azoospermia-like (DAZL) is a protein from Homo sapiens identified by UniProt accession Q92904, 295 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.

Target properties

Protein name	Deleted in azoospermia-like
UniProt accession	Q92904
Gene	DAZL
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (183)

Diseases linked to this target (Open Targets).

body height · score 0.32
response to opioid · score 0.31
Testicular Germ Cell Tumor · score 0.28
breast carcinoma · score 0.28
von Willebrand factor measurement · score 0.27
testicular carcinoma · score 0.21
mean corpuscular volume · score 0.11
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
mean corpuscular hemoglobin concentration · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92904-F1	alphafold	PREDICTED	57.44	—

Amino-acid sequence (295 residues)

MSTANPETPN STISREASTQ SSSAATSQGY ILPEGKIMPN TVFVGGIDVR MDETEIRSFF ARYGSVKEVK IITDRTGVSK GYGFVSFFND VDVQKIVESQ INFHGKKLKL GPAIRKQNLC AYHVQPRPLV FNHPPPPQFQ NVWTNPNTET YMQPTTTMNP ITQYVQAYPT YPNSPVQVIT GYQLPVYNYQ MPPQWPVGEQ RSYVVPPAYS AVNYHCNEVD PGAEVVPNEC SVHEATPPSG NGPQKKSVDR SIQTVVSCLF NPENRLRNSV VTQDDYFKDK RVHHFRRSRA MLKSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards