COP9 signalosome complex subunit 5 (COPS5)

About COP9 signalosome complex subunit 5

COP9 signalosome complex subunit 5 (COPS5) is a protein from Homo sapiens identified by UniProt accession Q92905, 334 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.

Target properties

Protein name	COP9 signalosome complex subunit 5
UniProt accession	Q92905
Gene	COPS5
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (183)

Diseases linked to this target (Open Targets).

Joubert syndrome · score 0.49
lung adenocarcinoma · score 0.19
neurodegenerative disease · score 0.18
breast adenocarcinoma · score 0.18
genetic disorder · score 0.12
cancer · score 0.11
neoplasm · score 0.11
hepatocellular carcinoma · score 0.11
non-small cell lung carcinoma · score 0.09
triple-negative breast cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92905-F1	alphafold	PREDICTED	86.32	—

Amino-acid sequence (334 residues)

MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards