About Transcription factor GATA-6
Transcription factor GATA-6 (GATA6) is a protein
from Homo sapiens identified by UniProt accession
Q92908, 595 residues long.
MolForge cross-references it against 0 known binders and
329 disease associations.
Target properties
| Protein name | Transcription factor GATA-6 |
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| UniProt accession | Q92908 |
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| Gene | GATA6 |
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| Organism | Homo sapiens |
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| Length | 595 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (329)
Diseases linked to this target (Open Targets).
- pancreatic hypoplasia-diabetes-congenital heart disease syndrome · score 0.79
- Pancreatic hypoplasia - diabetes - congenital heart disease · score 0.77
- atrioventricular septal defect 5 · score 0.73
- Tetralogy of Fallot · score 0.70
- atrial septal defect 9 · score 0.68
- conotruncal heart malformations · score 0.56
- congenital diaphragmatic hernia · score 0.55
- Abnormal cardiovascular system morphology · score 0.55
- neurodegenerative disease · score 0.54
- persistent truncus arteriosus · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92908-F1 | alphafold | PREDICTED | 52.59 | — |
Amino-acid sequence (595 residues)
MALTDGGWCL PKRFGAAGAD ASDSRAFPAR EPSTPPSPIS SSSSSCSRGG ERGPGGASNC GTPQLDTEAA AGPPARSLLL SSYASHPFGA PHGPSAPGVA GPGGNLSSWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA PEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLPG LPYHLQGSGS GPANHAGGAG AHPGWPQASA DSPPYGSGGG AAGGGAAGPG GAGSAAAHVS ARFPYSPSPP MANGAAREPG GYAAAGSGGA GGVSGGGSSL AAMGGREPQY SSLSAARPLN GTYHHHHHHH HHHPSPYSPY VGAPLTPAWP AGPFETPVLH SLQSRAGAPL PVPRGPSADL LEDLSESREC VNCGSIQTPL WRRDGTGHYL CNACGLYSKM NGLSRPLIKP QKRVPSSRRL GLSCANCHTT TTTLWRRNAE GEPVCNACGL YMKLHGVPRP LAMKKEGIQT RKRKPKNINK SKTCSGNSNN SIPMTPTSTS SNSDDCSKNT SPTTQPTASG AGAPVMTGAG ESTNPENSEL KYSGQDGLYI GVSLASPAEV TSSVRPDSWC ALALA
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