About Fibroblast growth factor 14
Fibroblast growth factor 14 (FGF14) is a protein
from Homo sapiens identified by UniProt accession
Q92915, 247 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Fibroblast growth factor 14 |
|---|
| UniProt accession | Q92915 |
|---|
| Gene | FGF14 |
|---|
| Organism | Homo sapiens |
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| Length | 247 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (196)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 27 · score 0.65
- spinocerebellar ataxia 27A · score 0.65
- late-onset spinocerebellar ataxia 27b · score 0.52
- neuroticism measurement · score 0.45
- PR interval · score 0.38
- Isaacs syndrome · score 0.37
- hereditary episodic ataxia · score 0.37
- cerebellar ataxia · score 0.34
- genetic disorder · score 0.34
- neuroimaging measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92915-F1 | alphafold | PREDICTED | 79.24 | — |
Amino-acid sequence (247 residues)
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ AMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK PGVTPSKSTS ASAIMNGGKP VNKSKTT
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