About G-patch domain and KOW motifs-containing protein
G-patch domain and KOW motifs-containing protein (GPKOW) is a protein
from Homo sapiens identified by UniProt accession
Q92917, 476 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | G-patch domain and KOW motifs-containing protein |
|---|
| UniProt accession | Q92917 |
|---|
| Gene | GPKOW |
|---|
| Organism | Homo sapiens |
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| Length | 476 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- holoprosencephaly-hypokinesia-congenital contractures syndrome · score 0.40
- systemic juvenile idiopathic arthritis · score 0.01
- pachyonychia congenita · score 0.00
- Microcephaly · score 0.00
- Hypopigmentation of the skin · score 0.00
- non-small cell lung carcinoma · score 0.00
- infect · score 0.00
- infection · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92917-F1 | alphafold | PREDICTED | 69.66 | — |
Amino-acid sequence (476 residues)
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK TVEGRELQSV KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV VSQAVKELIA ESKKSLEERE NAGVDPTLAI PMIQKGCTPS GEGADSEPRA ETVPEEANYE AVPVEAYGLA MLRGMGWKPG EGIGRTFNQV VKPRVNSLRP KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG LVPGGAVVVL SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA APRSQHWLHR DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR VLEGLREDML ETLVPKAEGD RVMVVLGPQT GRVGHLLSRD RARSRALVQL PRENQVVELH YDAICQYMGP SDTDDD
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