About Mitogen-activated protein kinase kinase kinase kinase 1
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) is a protein
from Homo sapiens identified by UniProt accession
Q92918, 833 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| UniProt accession | Q92918 |
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| Gene | MAP4K1 |
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| Organism | Homo sapiens |
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| Length | 833 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (76)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.11
- acute myeloid leukemia · score 0.09
- Systemic lupus erythematosus · score 0.09
- glioblastoma multiforme · score 0.07
- autoimmune disease · score 0.07
- C1 inhibitor deficiency · score 0.07
- Hashimoto's thyroiditis · score 0.06
- pemphigus vulgaris · score 0.06
- autosomal systemic lupus erythematosus type 16 · score 0.05
- Immunodeficiency due to a late component of complements deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92918-F1 | alphafold | PREDICTED | 68.20 | — |
Amino-acid sequence (833 residues)
MDVVDPDIFN RDPRDHYDLL QRLGGGTYGE VFKARDKVSG DLVALKMVKM EPDDDVSTLQ KEILILKTCR HANIVAYHGS YLWLQKLWIC MEFCGAGSLQ DIYQVTGSLS ELQISYVCRE VLQGLAYLHS QKKIHRDIKG ANILINDAGE VRLADFGISA QIGATLARRL SFIGTPYWMA PEVAAVALKG GYNELCDIWS LGITAIELAE LQPPLFDVHP LRVLFLMTKS GYQPPRLKEK GKWSAAFHNF IKVTLTKSPK KRPSATKMLS HQLVSQPGLN RGLILDLLDK LKNPGKGPSI GDIEDEEPEL PPAIPRRIRS THRSSSLGIP DADCCRRHME FRKLRGMETR PPANTARLQP PRDLRSSSPR KQLSESSDDD YDDVDIPTPA EDTPPPLPPK PKFRSPSDEG PGSMGDDGQL SPGVLVRCAS GPPPNSPRPG PPPSTSSPHL TAHSEPSLWN PPSRELDKPP LLPPKKEKMK RKGCALLVKL FNGCPLRIHS TAAWTHPSTK DQHLLLGAEE GIFILNRNDQ EATLEMLFPS RTTWVYSINN VLMSLSGKTP HLYSHSILGL LERKETRAGN PIAHISPHRL LARKNMVSTK IQDTKGCRAC CVAEGASSGG PFLCGALETS VVLLQWYQPM NKFLLVRQVL FPLPTPLSVF ALLTGPGSEL PAVCIGVSPG RPGKSVLFHT VRFGALSCWL GEMSTEHRGP VQVTQVEEDM VMVLMDGSVK LVTPEGSPVR GLRTPEIPMT EAVEAVAMVG GQLQAFWKHG VQVWALGSDQ LLQELRDPTL TFRLLGSPRL ECSGTISPHC NLLLPGSSNS PASASRVAGI TGL
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