About SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (SMARCD2) is a protein
from Homo sapiens identified by UniProt accession
Q92925, 531 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 |
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| UniProt accession | Q92925 |
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| Gene | SMARCD2 |
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| Organism | Homo sapiens |
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| Length | 531 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- Recurrent infection due to specific granule deficiency · score 0.70
- autosomal recessive severe congenital neutropenia · score 0.45
- genetic disorder · score 0.19
- endometrial cancer · score 0.18
- body height · score 0.14
- bilirubin measurement · score 0.12
- gastric adenocarcinoma · score 0.11
- hemoglobin measurement · score 0.11
- Premature ovarian insufficiency · score 0.11
- hematocrit · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92925-F1 | alphafold | PREDICTED | 76.14 | — |
Amino-acid sequence (531 residues)
MSGRGAGGFP LPPLSPGGGA VAAALGAPPP PAGPGMLPGP ALRGPGPAGG VGGPGAAAFR PMGPAGPAAQ YQRPGMSPGN RMPMAGLQVG PPAGSPFGAA APLRPGMPPT MMDPFRKRLL VPQAQPPMPA QRRGLKRRKM ADKVLPQRIR ELVPESQAYM DLLAFERKLD QTIARKRMEI QEAIKKPLTQ KRKLRIYISN TFSPSKAEGD SAGTAGTPGG TPAGDKVASW ELRVEGKLLD DPSKQKRKFS SFFKSLVIEL DKELYGPDNH LVEWHRMPTT QETDGFQVKR PGDLNVKCTL LLMLDHQPPQ YKLDPRLARL LGVHTQTRAA IMQALWLYIK HNQLQDGHER EYINCNRYFR QIFSCGRLRF SEIPMKLAGL LQHPDPIVIN HVISVDPNDQ KKTACYDIDV EVDDPLKAQM SNFLASTTNQ QEIASLDVKI HETIESINQL KTQRDFMLSF STDPQDFIQE WLRSQRRDLK IITDVIGNPE EERRAAFYHQ PWAQEAVGRH IFAKVQQRRQ ELEQVLGIRL T
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