About Exostosin-like 1
Exostosin-like 1 (EXTL1) is a protein
from Homo sapiens identified by UniProt accession
Q92935, 676 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Exostosin-like 1 |
|---|
| UniProt accession | Q92935 |
|---|
| Gene | EXTL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 676 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- forced expiratory volume · score 0.05
- peak expiratory flow · score 0.04
- mean corpuscular volume · score 0.03
- myxosarcoma · score 0.03
- glioblastoma multiforme · score 0.03
- neuroblastoma · score 0.03
- Tetralogy of Fallot · score 0.02
- carcinoma of liver and intrahepatic biliary tract · score 0.02
- neoplasm · score 0.01
- medulloblastoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92935-F1 | alphafold | PREDICTED | 79.53 | — |
Amino-acid sequence (676 residues)
MQSWRRRKSL WLALSASWLL LVLLGGFSLL RLALPPRPRP GASQGWPRWL DAELLQSFSQ PGELPEDAVS PPQAPHGGSC NWESCFDTSK CRGDGLKVFV YPAVGTISET HRRILASIEG SRFYTFSPAG ACLLLLLSLD AQTGECSSMP LQWNRGRNHL VLRLHPAPCP RTFQLGQAMV AEASPTVDSF RPGFDVALPF LPEAHPLRGG APGQLRQHSP QPGVALLALE EERGGWRTAD TGSSACPWDG RCEQDPGPGQ TQRQETLPNA TFCLISGHRP EAASRFLQAL QAGCIPVLLS PRWELPFSEV IDWTKAAIVA DERLPLQVLA ALQEMSPARV LALRQQTQFL WDAYFSSVEK VIHTTLEVIQ DRIFGTSAHP SLLWNSPPGA LLALSTFSTS PQDFPFYYLQ QGSRPEGRFS ALIWVGPPGQ PPLKLIQAVA GSQHCAQILV LWSNERPLPS RWPETAVPLT VIDGHRKVSD RFYPYSTIRT DAILSLDARS SLSTSEVDFA FLVWQSFPER MVGFLTSSHF WDEAHGGWGY TAERTNEFSM VLTTAAFYHR YYHTLFTHSL PKALRTLADE APTCVDVLMN FIVAAVTKLP PIKVPYGKQR QEAAPLAPGG PGPRPKPPAP APDCINQIAA AFGHMPLLSS RLRLDPVLFK DPVSVQRKKY RSLEKP
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