About Far upstream element-binding protein 2
Far upstream element-binding protein 2 (KHSRP) is a protein
from Homo sapiens identified by UniProt accession
Q92945, 711 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Far upstream element-binding protein 2 |
|---|
| UniProt accession | Q92945 |
|---|
| Gene | KHSRP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 711 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (98)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.09
- esophageal squamous cell carcinoma · score 0.07
- breast cancer · score 0.07
- nonpapillary renal cell carcinoma · score 0.07
- kidney disease · score 0.04
- familial juvenile hyperuricemic nephropathy type 2 · score 0.04
- Genetic renal or urinary tract malformation · score 0.03
- congenital hydronephrosis · score 0.03
- overhydrated hereditary stomatocytosis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92945-F1 | alphafold | PREDICTED | 62.05 | — |
Amino-acid sequence (711 residues)
MSDYSTGGPP PGPPPPAGGG GGAGGAGGGP PPGPPGAGDR GGGGPGGGGP GGGSAGGPSQ PPGGGGPGIR KDAFADAVQR ARQIAAKIGG DAATTVNNST PDFGFGGQKR QLEDGDQPES KKLASQGDSI SSQLGPIHPP PRTSMTEEYR VPDGMVGLII GRGGEQINKI QQDSGCKVQI SPDSGGLPER SVSLTGAPES VQKAKMMLDD IVSRGRGGPP GQFHDNANGG QNGTVQEIMI PAGKAGLVIG KGGETIKQLQ ERAGVKMILI QDGSQNTNVD KPLRIIGDPY KVQQACEMVM DILRERDQGG FGDRNEYGSR IGGGIDVPVP RHSVGVVIGR SGEMIKKIQN DAGVRIQFKQ DDGTGPEKIA HIMGPPDRCE HAARIINDLL QSLRSGPPGP PGGPGMPPGG RGRGRGQGNW GPPGGEMTFS IPTHKCGLVI GRGGENVKAI NQQTGAFVEI SRQLPPNGDP NFKLFIIRGS PQQIDHAKQL IEEKIEGPLC PVGPGPGGPG PAGPMGPFNP GPFNQGPPGA PPHAGGPPPH QYPPQGWGNT YPQWQPPAPH DPSKAAAAAA DPNAAWAAYY SHYYQQPPGP VPGPAPAPAA PPAQGEPPQP PPTGQSDYTK AWEEYYKKIG QQPQQPGAPP QQDYTKAWEE YYKKQAQVAT GGGPGAPPGS QPDYSAAWAE YYRQQAAYYG QTPGPGGPQP PPTQQGQQQA Q
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