About Glutaryl-CoA dehydrogenase, mitochondrial
Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) is a protein
from Homo sapiens identified by UniProt accession
Q92947, 438 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Glutaryl-CoA dehydrogenase, mitochondrial |
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| UniProt accession | Q92947 |
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| Gene | GCDH |
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| Organism | Homo sapiens |
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| Length | 438 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (122)
Diseases linked to this target (Open Targets).
- glutaryl-CoA dehydrogenase deficiency · score 0.86
- genetic disorder · score 0.51
- Dystonia · score 0.42
- Abnormality of metabolism/homeostasis · score 0.41
- mean corpuscular hemoglobin concentration · score 0.34
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.34
- hypomyelinating leukodystrophy 2 · score 0.34
- congenital dyserythropoietic anemia type 4 · score 0.34
- primary ciliary dyskinesia · score 0.34
- Congenital dyserythropoietic anemia type IV · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92947-F1 | alphafold | PREDICTED | 92.02 | — |
Amino-acid sequence (438 residues)
MALRGVSVRL LSRGPGLHVL RTWVSSAAQT EKGGRTQSQL AKSSRPEFDW QDPLVLEEQL TTDEILIRDT FRTYCQERLM PRILLANRNE VFHREIISEM GELGVLGPTI KGYGCAGVSS VAYGLLAREL ERVDSGYRSA MSVQSSLVMH PIYAYGSEEQ RQKYLPQLAK GELLGCFGLT EPNSGSDPSS METRAHYNSS NKSYTLNGTK TWITNSPMAD LFVVWARCED GCIRGFLLEK GMRGLSAPRI QGKFSLRASA TGMIIMDGVE VPEENVLPGA SSLGGPFGCL NNARYGIAWG VLGASEFCLH TARQYALDRM QFGVPLARNQ LIQKKLADML TEITLGLHAC LQLGRLKDQD KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH ALILGRAITG IQAFTASK
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