Forkhead box protein J1 (FOXJ1)

About Forkhead box protein J1

Forkhead box protein J1 (FOXJ1) is a protein from Homo sapiens identified by UniProt accession Q92949, 421 residues long. MolForge cross-references it against 0 known binders and 214 disease associations.

Target properties

Protein name	Forkhead box protein J1
UniProt accession	Q92949
Gene	FOXJ1
Organism	Homo sapiens
Length	421 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (214)

Diseases linked to this target (Open Targets).

ciliary dyskinesia, primary, 43 · score 0.64
Hydrocephalus · score 0.39
allergic rhinitis · score 0.38
primary ciliary dyskinesia · score 0.38
body height · score 0.28
genetic disorder · score 0.19
Heterotaxia · score 0.07
congenital heart disease · score 0.07
mirror movements 3 · score 0.06
heterotaxy, visceral, 9, autosomal, with male infertility · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92949-F1	alphafold	PREDICTED	58.11	—

Amino-acid sequence (421 residues)

MAESWLRLSG AGPAEEAGPE GGLEEPDALD DSLTSLQWLQ EFSILNAKAP ALPPGGTDPH GYHQVPGSAA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA PPGLQAPPPD DVDYATNPHV KPPYSYATLI CMAMQASKAT KITLSAIYKW ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI KVPREKDEPG KGGFWRIDPQ YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSAVPRAGP LTVNTEAQQL LREFEEATGE AGWGAGEGRL GHKRKQPLPK RVAKVPRPPS TLLPTPEEQG ELEPLKGNFD WEAIFDAGTL GGELGALEAL ELSPPLSPAS HVDVDLTIHG RHIDCPATWG PSVEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPLF EAGDATLASD LQDWASVGAF L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards