About Solute carrier organic anion transporter family member 2A1
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a protein
from Homo sapiens identified by UniProt accession
Q92959, 643 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Solute carrier organic anion transporter family member 2A1 |
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| UniProt accession | Q92959 |
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| Gene | SLCO2A1 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (145)
Diseases linked to this target (Open Targets).
- Pachydermoperiostosis · score 0.81
- colorectal cancer · score 0.45
- primary hypertrophic osteoarthropathy · score 0.38
- Parkinson disease · score 0.26
- neurodegenerative disease · score 0.26
- lysosomal storage disease · score 0.26
- multiple sclerosis · score 0.26
- Alzheimer disease · score 0.26
- colorectal adenoma · score 0.26
- cutaneous melanoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92959-F1 | alphafold | PREDICTED | 81.91 | — |
Amino-acid sequence (643 residues)
MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL IGIGGLFLAA GAFILTLPHF LSEPYQYTLA STGNNSRLQA ELCQKHWQDL PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA GIGTVPIQPF GISYVDDFSE PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN TAAVNLVPGD PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN KFLEKQYGTS AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI ATTIITISMI LCVPLFFMGC STPTVAEVYP PSTSSSIHPQ SPACRRDCSC PDSIFHPVCG DNGIEYLSPC HAGCSNINMS SATSKQLIYL NCSCVTGGSA SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV LRVVNQEEKS FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI
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