About GTP-binding protein Rit1
GTP-binding protein Rit1 (RIT1) is a protein
from Homo sapiens identified by UniProt accession
Q92963, 219 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | GTP-binding protein Rit1 |
|---|
| UniProt accession | Q92963 |
|---|
| Gene | RIT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 219 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- Noonan syndrome · score 0.81
- rasopathy · score 0.62
- Noonan syndrome and Noonan-related syndrome · score 0.53
- Abnormality of the cardiovascular system · score 0.53
- genetic disorder · score 0.46
- Non-immune hydrops fetalis · score 0.43
- congenital heart disease · score 0.34
- Short stature · score 0.27
- Downslanted palpebral fissures · score 0.27
- Hypertelorism · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92963-F1 | alphafold | PREDICTED | 87.14 | — |
Amino-acid sequence (219 residues)
MDSGTRPVGS CCSSPAGLSR EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH DPTIEDAYKI RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY SITDRRSFHE VREFKQLIYR VRRTDDTPVV LVGNKSDLKQ LRQVTKEEGL ALAREFSCPF FETSAAYRYY IDDVFHALVR EIRRKEKEAV LAMEKKSKPK NSVWKRLKSP FRKKKDSVT
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