Peroxisomal membrane protein PEX13 (PEX13)

About Peroxisomal membrane protein PEX13

Peroxisomal membrane protein PEX13 (PEX13) is a protein from Homo sapiens identified by UniProt accession Q92968, 403 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Peroxisomal membrane protein PEX13
UniProt accession	Q92968
Gene	PEX13
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 11B · score 0.77
peroxisome biogenesis disorder 11A (Zellweger) · score 0.77
Zellweger syndrome · score 0.73
peroxisome biogenesis disorder · score 0.60
neurodegenerative disease · score 0.48
Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.46
lysosomal storage disease · score 0.40
peroxisome biogenesis disorder, complementation group 7 · score 0.37
ulcerative colitis · score 0.33
multiple sclerosis · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92968-F1	alphafold	PREDICTED	64.94	—

Amino-acid sequence (403 residues)

MASQPPPPPK PWETRRIPGA GPGPGPGPTF QSADLGPTLM TRPGQPALTR VPPPILPRPS QQTGSSSVNT FRPAYSSFSS GYGAYGNSFY GGYSPYSYGY NGLGYNRLRV DDLPPSRFVQ QAEESSRGAF QSIESIVHAF ASVSMMMDAT FSAVYNSFRA VLDVANHFSR LKIHFTKVFS AFALVRTIRY LYRRLQRMLG LRRGSENEDL WAESEGTVAC LGAEDRAATS AKSWPIFLFF AVILGGPYLI WKLLSTHSDE VTDSINWASG EDDHVVARAE YDFAAVSEEE ISFRAGDMLN LALKEQQPKV RGWLLASLDG QTTGLIPANY VKILGKRKGR KTVESSKVSK QQQSFTNPTL TKGATVADSL DEQEAAFESV FVETNKVPVA PDSIGKDGEK QDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards