About Rho guanine nucleotide exchange factor 2
Rho guanine nucleotide exchange factor 2 (ARHGEF2) is a protein
from Homo sapiens identified by UniProt accession
Q92974, 986 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 2 |
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| UniProt accession | Q92974 |
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| Gene | ARHGEF2 |
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| Organism | Homo sapiens |
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| Length | 986 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (134)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with midbrain and hindbrain malformations · score 0.48
- thyroid gland adenocarcinoma · score 0.22
- breast adenocarcinoma · score 0.18
- Microcephaly · score 0.14
- myoepithelial tumor · score 0.11
- risk-taking behaviour · score 0.10
- mathematical ability · score 0.10
- Crohn's disease · score 0.09
- body mass index · score 0.09
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92974-F1 | alphafold | PREDICTED | 69.19 | — |
Amino-acid sequence (986 residues)
MSRIESLTRA RIDRSRELAS KTREKEKMKE AKDARYTNGH LFTTISVSGM TMCYACNKSI TAKEALICPT CNVTIHNRCK DTLANCTKVK QKQQKAALLK NNTALQSVSL RSKTTIRERP SSAIYPSDSF RQSLLGSRRG RSSLSLAKSV STTNIAGHFN DESPLGLRRI LSQSTDSLNM RNRTLSVESL IDEAEVIYSE LMSDFEMDEK DFAADSWSLA VDSSFLQQHK KEVMKQQDVI YELIQTELHH VRTLKIMTRL FRTGMLEELH LEPGVVQGLF PCVDELSDIH TRFLSQLLER RRQALCPGST RNFVIHRLGD LLISQFSGPS AEQMCKTYSE FCSRHSKALK LYKELYARDK RFQQFIRKVT RPAVLKRHGV QECILLVTQR ITKYPLLISR ILQHSHGIEE ERQDLTTALG LVKELLSNVD EGIYQLEKGA RLQEIYNRMD PRAQTPVPGK GPFGREELLR RKLIHDGCLL WKTATGRFKD VLVLLMTDVL VFLQEKDQKY IFPTLDKPSV VSLQNLIVRD IANQEKGMFL ISAAPPEMYE VHTASRDDRS TWIRVIQQSV RTCPSREDFP LIETEDEAYL RRIKMELQQK DRALVELLRE KVGLFAEMTH FQAEEDGGSG MALPTLPRGL FRSESLESPR GERLLQDAIR EVEGLKDLLV GPGVELLLTP REPALPLEPD SGGNTSPGVT ANGEARTFNG SIELCRADSD SSQRDRNGNQ LRSPQEEALQ RLVNLYGLLH GLQAAVAQQD TLMEARFPEG PERREKLCRA NSRDGEAGRA GAAPVAPEKQ ATELALLQRQ HALLQEELRR CRRLGEERAT EAGSLEARLR ESEQARALLE REAEEARRQL AALGQTEPLP AEAPWARRPV DPRRRSLPAG DALYLSFNPP QPSRGTDRLD LPVTTRSVHR NFEDRERQEL GSPEERLQDS SDPDTGSEEE GSSRLSPPHS PRDFTRMQDI PEETESRDGE AVASES
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