About Ribosomal RNA small subunit methyltransferase NEP1
Ribosomal RNA small subunit methyltransferase NEP1 (EMG1) is a protein
from Homo sapiens identified by UniProt accession
Q92979, 244 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Ribosomal RNA small subunit methyltransferase NEP1 |
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| UniProt accession | Q92979 |
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| Gene | EMG1 |
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| Organism | Homo sapiens |
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| Length | 244 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- Bowen-Conradi syndrome · score 0.61
- mean corpuscular hemoglobin concentration · score 0.19
- oleic acid measurement · score 0.16
- genetic disorder · score 0.16
- fatty acid measurement · score 0.15
- reticulocyte count · score 0.15
- Red cell distribution width · score 0.10
- neurodegenerative disease · score 0.09
- mean reticulocyte volume · score 0.08
- melanoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92979-F1 | alphafold | PREDICTED | 88.99 | — |
Amino-acid sequence (244 residues)
MAAPSDGFKP RERSGGEQAQ DWDALPPKRP RLGAGNKIGG RRLIVVLEGA SLETVKVGKT YELLNCDKHK SILLKNGRDP GEARPDITHQ SLLMLMDSPL NRAGLLQVYI HTQKNVLIEV NPQTRIPRTF DRFCGLMVQL LHKLSVRAAD GPQKLLKVIK NPVSDHFPVG CMKVGTSFSI PVVSDVRELV PSSDPIVFVV GAFAHGKVSV EYTEKMVSIS NYPLSAALTC AKLTTAFEEV WGVI
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