About Interferon regulatory factor 7
Interferon regulatory factor 7 (IRF7) is a protein
from Homo sapiens identified by UniProt accession
Q92985, 503 residues long.
MolForge cross-references it against 0 known binders and
409 disease associations.
Target properties
| Protein name | Interferon regulatory factor 7 |
|---|
| UniProt accession | Q92985 |
|---|
| Gene | IRF7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 503 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (409)
Diseases linked to this target (Open Targets).
- immunodeficiency 39 · score 0.57
- systemic lupus erythematosus · score 0.33
- hypothyroidism · score 0.22
- lung adenocarcinoma · score 0.20
- endometrial cancer · score 0.18
- breast adenocarcinoma · score 0.18
- systemic scleroderma · score 0.16
- esophageal cancer · score 0.15
- Thalassemia · score 0.14
- myositis · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92985-F1 | alphafold | PREDICTED | 68.06 | — |
Amino-acid sequence (503 residues)
MALAPERAAP RVLFGEWLLG EISSGCYEGL QWLDEARTCF RVPWKHFARK DLSEADARIF KAWAVARGRW PPSSRGGGPP PEAETAERAG WKTNFRCALR STRRFVMLRD NSGDPADPHK VYALSRELCW REGPGTDQTE AEAPAAVPPP QGGPPGPFLA HTHAGLQAPG PLPAPAGDKG DLLLQAVQQS CLADHLLTAS WGADPVPTKA PGEGQEGLPL TGACAGGPGL PAGELYGWAV ETTPSPGPQP AALTTGEAAA PESPHQAEPY LSPSPSACTA VQEPSPGALD VTIMYKGRTV LQKVVGHPSC TFLYGPPDPA VRATDPQQVA FPSPAELPDQ KQLRYTEELL RHVAPGLHLE LRGPQLWARR MGKCKVYWEV GGPPGSASPS TPACLLPRNC DTPIFDFRVF FQELVEFRAR QRRGSPRYTI YLGFGQDLSA GRPKEKSLVL VKLEPWLCRV HLEGTQREGV SSLDSSSLSL CLSSANSLYD DIECFLMELE QPA
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