Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1)

About Polyribonucleotide 5'-hydroxyl-kinase Clp1

Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) is a protein from Homo sapiens identified by UniProt accession Q92989, 425 residues long. MolForge cross-references it against 0 known binders and 478 disease associations.

Target properties

Protein name	Polyribonucleotide 5'-hydroxyl-kinase Clp1
UniProt accession	Q92989
Gene	CLP1
Organism	Homo sapiens
Length	425 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (478)

Diseases linked to this target (Open Targets).

pontocerebellar hypoplasia type 10 · score 0.78
Non-syndromic pontocerebellar hypoplasia · score 0.27
pontocerebellar hypoplasia · score 0.27
genetic disorder · score 0.19
hepatocellular carcinoma · score 0.18
gastric intestinal type adenocarcinoma · score 0.18
breast carcinoma · score 0.18
colorectal adenocarcinoma · score 0.18
cutaneous melanoma · score 0.18
head and neck squamous cell carcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92989-F1	alphafold	PREDICTED	93.81	—

Amino-acid sequence (425 residues)

MGEEANDDKK PTTKFELERE TELRFEVEAS QSVQLELLTG MAEIFGTELT RNKKFTFDAG AKVAVFTWHG CSVQLSGRTE VAYVSKDTPM LLYLNTHTAL EQMRRQAEKE EERGPRVMVV GPTDVGKSTV CRLLLNYAVR LGRRPTYVEL DVGQGSVSIP GTMGALYIER PADVEEGFSI QAPLVYHFGS TTPGTNIKLY NKITSRLADV FNQRCEVNRR ASVSGCVINT CGWVKGSGYQ ALVHAASAFE VDVVVVLDQE RLYNELKRDL PHFVRTVLLP KSGGVVERSK DFRRECRDER IREYFYGFRG CFYPHAFNVK FSDVKIYKVG APTIPDSCLP LGMSQEDNQL KLVPVTPGRD MVHHLLSVST AEGTEENLSE TSVAGFIVVT SVDLEHQVFT VLSPAPRPLP KNFLLIMDIR FMDLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards