About Histone acetyltransferase KAT5
Histone acetyltransferase KAT5 (KAT5) is a protein
from Homo sapiens identified by UniProt accession
Q92993, 513 residues long.
MolForge cross-references it against 0 known binders and
205 disease associations.
Target properties
| Protein name | Histone acetyltransferase KAT5 |
|---|
| UniProt accession | Q92993 |
|---|
| Gene | KAT5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 513 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (205)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities · score 0.62
- neurodegenerative disease · score 0.57
- cancer · score 0.54
- Microcephaly · score 0.49
- Sleep Disorder · score 0.48
- Intellectual disability · score 0.48
- Seizure · score 0.48
- Abnormality of the face · score 0.48
- Orofacial cleft · score 0.48
- Atypical behavior · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92993-F1 | alphafold | PREDICTED | 75.33 | — |
Amino-acid sequence (513 residues)
MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVPASAQ ASGKTLPIPV QITLRFNLPK EREAIPGGEP DQPLSSSSCL QPNHRSTKRK VEVVSPATPV PSETAPASVF PQNGAARRAV AAQPGRKRKS NCLGTDEDSQ DSSDGIPSAP RMTGSLVSDR SHDDIVTRMK NIECIELGRH RLKPWYFSPY PQELTTLPVL YLCEFCLKYG RSLKCLQRHL TKCDLRHPPG NEIYRKGTIS FFEIDGRKNK SYSQNLCLLA KCFLDHKTLY YDTDPFLFYV MTEYDCKGFH IVGYFSKEKE STEDYNVACI LTLPPYQRRG YGKLLIEFSY ELSKVEGKTG TPEKPLSDLG LLSYRSYWSQ TILEILMGLK SESGERPQIT INEISEITSI KKEDVISTLQ YLNLINYYKG QYILTLSEDI VDGHERAMLK RLLRIDSKCL HFTPKDWSKR GKW
Explore Histone acetyltransferase KAT5 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets