About Tumor necrosis factor receptor superfamily member 25
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is a protein
from Homo sapiens identified by UniProt accession
Q93038, 417 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 25 |
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| UniProt accession | Q93038 |
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| Gene | TNFRSF25 |
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| Organism | Homo sapiens |
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| Length | 417 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (235)
Diseases linked to this target (Open Targets).
- neuronopathy, distal hereditary motor, autosomal recessive 4 · score 0.19
- distal hereditary motor neuropathy · score 0.16
- multiple sclerosis · score 0.11
- colitis · score 0.10
- sarcoidosis · score 0.09
- chronic lymphocytic leukemia · score 0.08
- cancer · score 0.08
- type 2 diabetes mellitus · score 0.06
- Rheumatoid arthritis · score 0.06
- acute respiratory distress syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q93038-F1 | alphafold | PREDICTED | 72.32 | — |
Amino-acid sequence (417 residues)
MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG MEALTPPPAT HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF VRTLGLREAE IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM GLDGCVEDLR SRLQRGP
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