Ecto-ADP-ribosyltransferase 4 (ART4)

About Ecto-ADP-ribosyltransferase 4

Ecto-ADP-ribosyltransferase 4 (ART4) is a protein from Homo sapiens identified by UniProt accession Q93070, 314 residues long. MolForge cross-references it against 0 known binders and 632 disease associations.

Target properties

Protein name	Ecto-ADP-ribosyltransferase 4
UniProt accession	Q93070
Gene	ART4
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (632)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.23
blood protein measurement · score 0.16
grip strength measurement · score 0.13
creatinine measurement · score 0.11
body height · score 0.06
BMI-adjusted hip circumference · score 0.06
osteoarthritis, hand · score 0.06
sitting height measurement · score 0.05
Blackfan-Diamond anemia · score 0.05
bone fracture · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q93070-F1	alphafold	PREDICTED	80.27	—

Amino-acid sequence (314 residues)

MGPLINRCKK ILLPTTVPPA TMRIWLLGGL LPFLLLLSGL QRPTEGSEVA IKIDFDFAPG SFDDQYQGCS KQVMEKLTQG DYFTKDIEAQ KNYFRMWQKA HLAWLNQGKV LPQNMTTTHA VAILFYTLNS NVHSDFTRAM ASVARTPQQY ERSFHFKYLH YYLTSAIQLL RKDSIMENGT LCYEVHYRTK DVHFNAYTGA TIRFGQFLST SLLKEEAQEF GNQTLFTIFT CLGAPVQYFS LKKEVLIPPY ELFKVINMSY HPRGDWLQLR STGNLSTYNC QLLKASSKKC IPDPIAIASL SFLTSVIIFS KSRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards