About Selenocysteine insertion sequence-binding protein 2-like
Selenocysteine insertion sequence-binding protein 2-like (SECISBP2L) is a protein
from Homo sapiens identified by UniProt accession
Q93073, 1101 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Selenocysteine insertion sequence-binding protein 2-like |
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| UniProt accession | Q93073 |
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| Gene | SECISBP2L |
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| Organism | Homo sapiens |
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| Length | 1101 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- diastolic blood pressure · score 0.39
- calcium measurement · score 0.39
- mean platelet volume · score 0.37
- lung adenocarcinoma · score 0.29
- FEV/FVC ratio · score 0.25
- platelet count · score 0.25
- nontoxic goiter · score 0.21
- alcohol consumption measurement · score 0.20
- thyroid disease · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q93073-F1 | alphafold | PREDICTED | 52.89 | — |
Amino-acid sequence (1101 residues)
MDRAPTEQNV KLSAEVEPFI PQKKSPDTFM IPMALPNDNG SVSGVEPTPI PSYLITCYPF VQENQSNRQF PLYNNDIRWQ QPNPNPTGPY FAYPIISAQP PVSTEYTYYQ LMPAPCAQVM GFYHPFPTPY SNTFQAANTV NAITTECTER PSQLGQVFPL SSHRSRNSNR GSVVPKQQLL QQHIKSKRPL VKNVATQKET NAAGPDSRSK IVLLVDASQQ TDFPSDIANK SLSETTATML WKSKGRRRRA SHPTAESSSE QGASEADIDS DSGYCSPKHS NNQPAAGALR NPDSGTMNHV ESSMCAGGVN WSNVTCQATQ KKPWMEKNQT FSRGGRQTEQ RNNSQVGFRC RGHSTSSERR QNLQKRPDNK HLSSSQSHRS DPNSESLYFE DEDGFQELNE NGNAKDENIQ QKLSSKVLDD LPENSPINIV QTPIPITTSV PKRAKSQKKK ALAAALATAQ EYSEISMEQK KLQEALSKAA GKKNKTPVQL DLGDMLAALE KQQQAMKARQ ITNTRPLSYT VVTAASFHTK DSTNRKPLTK SQPCLTSFNS VDIASSKAKK GKEKEIAKLK RPTALKKVIL KEREEKKGRL TVDHNLLGSE EPTEMHLDFI DDLPQEIVSQ EDTGLSMPSD TSLSPASQNS PYCMTPVSQG SPASSGIGSP MASSTITKIH SKRFREYCNQ VLCKEIDECV TLLLQELVSF QERIYQKDPV RAKARRRLVM GLREVTKHMK LNKIKCVIIS PNCEKIQSKG GLDEALYNVI AMAREQEIPF VFALGRKALG RCVNKLVPVS VVGIFNYFGA ESLFNKLVEL TEEARKAYKD MVAAMEQEQA EEALKNVKKV PHHMGHSRNP SAASAISFCS VISEPISEVN EKEYETNWRN MVETSDGLEA SENEKEVSCK HSTSEKPSKL PFDTPPIGKQ PSLVATGSTT SATSAGKSTA SDKEEVKPDD LEWASQQSTE TGSLDGSCRD LLNSSITSTT STLVPGMLEE EEDEDEEEEE DYTHEPISVE VQLNSRIESW VSETQRTMET LQLGKTLNGS EEDNVEQSGE EEAEAPEVLE PGMDSEAWTA DQQASPGQQK SSNCSSLNKE HSDSNYTTQT T
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