About 3'-5' RNA nuclease TATDN2
3'-5' RNA nuclease TATDN2 (TATDN2) is a protein
from Homo sapiens identified by UniProt accession
Q93075, 761 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | 3'-5' RNA nuclease TATDN2 |
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| UniProt accession | Q93075 |
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| Gene | TATDN2 |
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| Organism | Homo sapiens |
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| Length | 761 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- pancreatic adenocarcinoma · score 0.16
- self reported educational attainment · score 0.15
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
- age related macular degeneration 7 · score 0.06
- age related macular degeneration 11 · score 0.06
- age related macular degeneration 4 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q93075-F1 | alphafold | PREDICTED | 59.02 | — |
Amino-acid sequence (761 residues)
MASERGKVKH NWSSTSEGCP RKRSCLREPC DVAPSSRPAQ RSASRSGGPS SPKRLKAQKE DDVACSRRLS WGSSRRRNNS SSSFSPHFLG PGVGGAASKG CLIRNTRGFL SSGGSPLRPA NASLEEMASL EEEACSLKVD SKDSSHNSTN SEFAAEAEGQ NDTIEEPNKV QKRKRDRLRD QGSTMIYLKA IQGILGKSMP KRKGEAATRA KPSAAEHPSH GEGPARSEGP AKTAEGAARS VTVTAAQKEK DATPEVSMEE DKTVPERSSF YDRRVVIDPQ EKPSEEPLGD RRTVIDKCSP PLEFLDDSDS HLEIQKHKDR EVVMEHPSSG SDWSDVEEIS TVRFSQEEPV SLKPSAVPEP SSFTTDYVMY PPHLYSSPWC DYASYWTSSP KPSSYPSTGS SSNDAAQVGK SSRSRMSDYS PNSTGSVQNT SRDMEASEEG WSQNSRSFRF SRSSEEREVK EKRTFQEEMP PRPCGGHASS SLPKSHLEPS LEEGFIDTHC HLDMLYSKLS FQGTFTKFRK IYSSSFPKEF QGCISDFCDP RTLTDCLWEE LLKEDLVWGA FGCHPHFARY YSESQERNLL QALRHPKAVA FGEMGLDYSY KCTTPVPEQH KVFERQLQLA VSLKKPLVIH CREADEDLLE IMKKFVPPDY KIHRHCFTGS YPVIEPLLKY FPNMSVGFTA VLTYSSAWEA REALRQIPLE RIIVETDAPY FLPRQVPKSL CQYAHPGLAL HTVREIARVK DQPLSLTLAA LRENTSRLYS L
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