Betaine--homocysteine S-methyltransferase 1 (BHMT)

About Betaine--homocysteine S-methyltransferase 1

Betaine--homocysteine S-methyltransferase 1 (BHMT) is a protein from Homo sapiens identified by UniProt accession Q93088, 406 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.

Target properties

Protein name	Betaine--homocysteine S-methyltransferase 1
UniProt accession	Q93088
Gene	BHMT
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q93088-F1	alphafold	PREDICTED	92.61	—

Amino-acid sequence (406 residues)

MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSETEVKKV FLQQLEVFMK KNVDFLIAEY FEHVEEAVWA VETLIASGKP VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL KAHLMSQPLA YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE YWENLRIASG RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK QKFKSQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards