Protein tyrosine phosphatase type IVA 1 (PTP4A1)

About Protein tyrosine phosphatase type IVA 1

Protein tyrosine phosphatase type IVA 1 (PTP4A1) is a protein from Homo sapiens identified by UniProt accession Q93096, 173 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Protein tyrosine phosphatase type IVA 1
UniProt accession	Q93096
Gene	PTP4A1
Organism	Homo sapiens
Length	173 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (84)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
body mass index · score 0.33
asthma · score 0.28
type 2 diabetes mellitus · score 0.23
respiratory system disease · score 0.23
testosterone measurement · score 0.17
esophageal squamous cell carcinoma · score 0.08
intrahepatic cholangiocarcinoma · score 0.07
oral squamous cell carcinoma · score 0.07
glioblastoma multiforme · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q93096-F1	alphafold	PREDICTED	88.06	—

Amino-acid sequence (173 residues)

MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards