Homogentisate 1,2-dioxygenase (HGD)

About Homogentisate 1,2-dioxygenase

Homogentisate 1,2-dioxygenase (HGD) is a protein from Homo sapiens identified by UniProt accession Q93099, 445 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Homogentisate 1,2-dioxygenase
UniProt accession	Q93099
Gene	HGD
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

alkaptonuria · score 0.85
genetic disorder · score 0.19
Barrett's esophagus · score 0.07
pentosuria · score 0.07
hyperdibasic aminoaciduria type 1 · score 0.07
iminoglycinuria · score 0.07
uridine-cytidineuria · score 0.06
isolated sedoheptulokinase deficiency · score 0.06
cystinuria · score 0.06
seizures-intellectual disability due to hydroxylysinuria syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q93099-F1	alphafold	PREDICTED	96.78	—

Amino-acid sequence (445 residues)

MAELKYISGF GNECSSEDPR CPGSLPEGQN NPQVCPYNLY AEQLSGSAFT CPRSTNKRSW LYRILPSVSH KPFESIDEGQ VTHNWDEVDP DPNQLRWKPF EIPKASQKKV DFVSGLHTLC GAGDIKSNNG LAIHIFLCNT SMENRCFYNS DGDFLIVPQK GNLLIYTEFG KMLVQPNEIC VIQRGMRFSI DVFEETRGYI LEVYGVHFEL PDLGPIGANG LANPRDFLIP IAWYEDRQVP GGYTVINKYQ GKLFAAKQDV SPFNVVAWHG NYTPYKYNLK NFMVINSVAF DHADPSIFTV LTAKSVRPGV AIADFVIFPP RWGVADKTFR PPYYHRNCMS EFMGLIRGHY EAKQGGFLPG GGSLHSTMTP HGPDADCFEK ASKVKLAPER IADGTMAFMF ESSLSLAVTK WGLKASRCLD ENYHKCWEPL KSHFTPNSRN PAEPN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards