Thymic stromal lymphopoietin (TSLP)

About Thymic stromal lymphopoietin

Thymic stromal lymphopoietin (TSLP) is a protein from Homo sapiens identified by UniProt accession Q969D9, 159 residues long. MolForge cross-references it against 0 known binders and 433 disease associations.

Target properties

Protein name	Thymic stromal lymphopoietin
UniProt accession	Q969D9
Gene	TSLP
Organism	Homo sapiens
Length	159 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (433)

Diseases linked to this target (Open Targets).

asthma · score 0.66
eosinophil count · score 0.51
eosinophil percentage of leukocytes · score 0.40
Nasal Cavity Polyp · score 0.40
allergic rhinitis · score 0.38
allergic disease · score 0.37
Airway obstruction · score 0.37
childhood onset asthma · score 0.36
seasonal allergic rhinitis · score 0.34
eosinophilic esophagitis · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969D9-F1	alphafold	PREDICTED	79.08	—

Amino-acid sequence (159 residues)

MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR FNRPLLKQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards