Liver-expressed antimicrobial peptide 2 (LEAP2)

About Liver-expressed antimicrobial peptide 2

Liver-expressed antimicrobial peptide 2 (LEAP2) is a protein from Homo sapiens identified by UniProt accession Q969E1, 77 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Liver-expressed antimicrobial peptide 2
UniProt accession	Q969E1
Gene	LEAP2
Organism	Homo sapiens
Length	77 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
breast adenocarcinoma · score 0.10
alcohol consumption measurement · score 0.10
monocyte percentage of leukocytes · score 0.09
granulocyte percentage of myeloid white cells · score 0.09
blood protein measurement · score 0.08
C-reactive protein measurement · score 0.08
insulin like growth factor measurement · score 0.08
type 2 diabetes mellitus · score 0.08
glomerular filtration rate · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969E1-F1	alphafold	PREDICTED	76.71	—

Amino-acid sequence (77 residues)

MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI GASCRDDSEC ITRLCRKRRC SLSVAQE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards