About Pre-rRNA-processing protein TSR2 homolog
Pre-rRNA-processing protein TSR2 homolog (TSR2) is a protein
from Homo sapiens identified by UniProt accession
Q969E8, 191 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Pre-rRNA-processing protein TSR2 homolog |
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| UniProt accession | Q969E8 |
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| Gene | TSR2 |
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| Organism | Homo sapiens |
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| Length | 191 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.52
- Aarskog-Scott syndrome, X-linked · score 0.48
- Diamond-Blackfan anemia · score 0.46
- genetic disorder · score 0.17
- neoplasm · score 0.02
- laryngeal squamous cell carcinoma · score 0.01
- Microcephaly · score 0.00
- Systemic lupus erythematosus · score 0.00
- pontocerebellar hypoplasia · score 0.00
- Treacher-Collins syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969E8-F1 | alphafold | PREDICTED | 74.07 | — |
Amino-acid sequence (191 residues)
MAGAAEDARA LFRAGVCAAL EAWPALQIAV ENGFGGVHSQ EKAKWLGGAV EDYFMRNADL ELDEVEDFLG ELLTNEFDTV VEDGSLPQVS QQLQTMFHHF QRGDGAALRE MASCITQRKC KVTATALKTA RETDEDEDDV DSVEEMEVTA TNDGAATDGV CPQPEPSDPD AQTIKEEDIV EDGWTIVRRK K
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