Protein naked cuticle homolog 2 (NKD2)

About Protein naked cuticle homolog 2

Protein naked cuticle homolog 2 (NKD2) is a protein from Homo sapiens identified by UniProt accession Q969F2, 451 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Protein naked cuticle homolog 2
UniProt accession	Q969F2
Gene	NKD2
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.41
erythrocyte count · score 0.39
Red cell distribution width · score 0.39
mean corpuscular hemoglobin concentration · score 0.38
hemoglobin measurement · score 0.32
red blood cell density measurement · score 0.25
PR interval · score 0.21
drug use measurement · score 0.10
acute myeloid leukemia · score 0.07
neoplasm · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969F2-F1	alphafold	PREDICTED	55.45	—

Amino-acid sequence (451 residues)

MGKLQSKHAA AARKRRESPE GDSFVASAYA SGRKGAEEAE RRARDKQELP NGDPKEGPFR EDQCPLQVAL PAEKAEGREH PGQLLSADDG ERAANREGPR GPGGQRLNID ALQCDVSVEE DDRQEWTFTL YDFDNCGKVT REDMSSLMHT IYEVVDASVN HSSGSSKTLR VKLTVSPEPS SKRKEGPPAG QDREPTRCRM EGELAEEPRV ADRRLSAHVR RPSTDPQPCS ERGPYCVDEN TERRNHYLDL AGIENYTSRF GPGSPPVQAK QEPQGRASHL QARSRSQEPD THAVHHRRSQ VLVEHVVPAS EPAARALDTQ PRPKGPEKQF LKSPKGSGKP PGVPASSKSG KAFSYYLPAV LPPQAPQDGH HLPQPPPPPY GHKRYRQKGR EGHSPLKAPH AQPATVEHEV VRDLPPTPAG EGYAVPVIQR HEHHHHHEHH HHHHHHHFHP S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards