KiSS-1 receptor (KISS1R)

About KiSS-1 receptor

KiSS-1 receptor (KISS1R) is a protein from Homo sapiens identified by UniProt accession Q969F8, 398 residues long. MolForge cross-references it against 0 known binders and 474 disease associations.

Target properties

Protein name	KiSS-1 receptor
UniProt accession	Q969F8
Gene	KISS1R
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (474)

Diseases linked to this target (Open Targets).

Kallmann syndrome · score 0.64
Central precocious puberty · score 0.45
hypogonadotropic hypogonadism · score 0.41
neurodegenerative disease · score 0.37
pituitary stalk interruption syndrome · score 0.28
heel bone mineral density · score 0.27
disease of genitourinary system · score 0.27
ovarian cancer · score 0.26
genetic disorder · score 0.19
pancreatic adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969F8-F1	alphafold	PREDICTED	75.26	—

Amino-acid sequence (398 residues)

MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA ALMLLGLVGN SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA LLYPLPGWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL HRLSPGPRAY CSEAFPSRAL ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP ADSALQGQVL AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR PGPSDPAAPH AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards