About LIM/homeobox protein Lhx4
LIM/homeobox protein Lhx4 (LHX4) is a protein
from Homo sapiens identified by UniProt accession
Q969G2, 390 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | LIM/homeobox protein Lhx4 |
|---|
| UniProt accession | Q969G2 |
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| Gene | LHX4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 390 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- short stature-pituitary and cerebellar defects-small sella turcica syndrome · score 0.72
- Short stature - pituitary and cerebellar defects - small sella turcica · score 0.70
- Combined pituitary hormone deficiencies, genetic forms · score 0.61
- neurodegenerative disease · score 0.53
- hypopituitarism · score 0.38
- pituitary stalk interruption syndrome · score 0.37
- hypothyroidism due to deficient transcription factors involved in pituitary development or function · score 0.37
- body height · score 0.27
- genetic disorder · score 0.19
- pituitary hormone deficiency, combined, 1 · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969G2-F1 | alphafold | PREDICTED | 67.30 | — |
Amino-acid sequence (390 residues)
MMQSATVPAE GAVKGLPEML GVPMQQIPQC AGCNQHILDK FILKVLDRHW HSSCLKCADC QMQLADRCFS RAGSVYCKED FFKRFGTKCT ACQQGIPPTQ VVRKAQDFVY HLHCFACIIC NRQLATGDEF YLMEDGRLVC KEDYETAKQN DDSEAGAKRP RTTITAKQLE TLKNAYKNSP KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RHRWGQFYKS VKRSRGSSKQ EKESSAEDCG VSDSELSFRE DQILSELGHT NRIYGNVGDV TGGQLMNGSF SMDGTGQSYQ DLRDGSPYGI PQSPSSISSL PSHAPLLNGL DYTVDSNLGI IAHAGQGVSQ TLRAMAGGPT SDISTGSSVG YPDFPTSPGS WLDEMDHPPF
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