About SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) is a protein
from Homo sapiens identified by UniProt accession
Q969G3, 411 residues long.
MolForge cross-references it against 0 known binders and
224 disease associations.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 |
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| UniProt accession | Q969G3 |
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| Gene | SMARCE1 |
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| Organism | Homo sapiens |
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| Length | 411 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (224)
Diseases linked to this target (Open Targets).
- familial meningioma · score 0.74
- Coffin-Siris syndrome · score 0.67
- hereditary neoplastic syndrome · score 0.54
- Inherited cancer-predisposing syndrome · score 0.54
- neurodegenerative disease · score 0.53
- meningioma · score 0.42
- Transitional Meningioma · score 0.37
- Hepatobiliary Neoplasm · score 0.37
- colorectal adenocarcinoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969G3-F1 | alphafold | PREDICTED | 69.55 | — |
Amino-acid sequence (411 residues)
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII GGMWRDLTDE EKQEYLNEYE AEKIEYNESM KAYHNSPAYL AYINAKSRAE AALEEESRQR QSRMEKGEPY MSIQPAEDPD DYDDGFSMKH TATARFQRNH RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK LEAELLQIEE RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIAAEIA QAEEQARKRQ EEREKEAAEQ AERSQSSIVP EEEQAANKGE EKKDDENIPM ETEETHLEET TESQQNGEEG TSTPEDKESG QEGVDSMAEE GTSDSNTGSE SNSATVEEPP TDPIPEDEKK E
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